First world vs. third world paradox

under construction

Most TB cases occur in the poorer third world countries, while it is much less of a problem in western countries. Why is this? It appears that the main drivers of TB in poorer countries are overcrowding, lack of sanitation in some cases, malnutrition and poverty related issues. Other diseases can cause latent TB to become active. Being HIV positive increases the chance of TB becoming active, too. Another possibility is genetic resistance. TB was a problem in Europe starting about the 1400s, reached a peak in the 1700s and declined throughout the 20th century, whereas TB was rare in most parts of the world prior to the 1800s. This appears to have resulted in European decendents having a higher average resistance compared to most other races and ethnic groups in the world.

Look at the list under
Incidence rates decreased for all racial and ethnic groups
Note that whites are at the bottom of the list

Compare that to the list in the article that was published in 1912 here.

Genetics and Resistance to Tuberculosis
William W. Stead MD
American College of Physicians 1992

First genetic resistance factor against tuberculosis infection identified

Genetic susceptibility to tuberculosis in human populations
Richard Bellamy
Thorax 1998;53:588 - 593